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For traumatic brain injury specifically, P21 addresses what is perhaps the most frustrating aspect of recovery: the loss of neural architecture

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These protective responses have been associated with coordinated biological actions involving vascular support, regenerative signaling, and regulation of inflammatory activity, collectively contributing to enhanced tissue resilience and recovery in injury models

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Lipid nanoparticle platforms, similar to those used in mRNA vaccines, can even permit in situ expression of therapeutic peptides or immunomodulatory molecules directly within the CNS